Yuki Bhambri has pulled out of the French Open due to the ankle injury as Sania Mirza crashed out of the women's singles event.

The reigning Australian Open boys champion had sustained the injury while playing in doubles in an ITF Futures event in Kuwait last week.

Yuki, who became the first Indian to win Australian Open boys singles and fourth from the country to claim a junior Grand Slam, said he had been advised by doctors to take rest for at least 15 days to recover from his injury.

"My ankle is a bit swollen and I am having problems in running. I can play with ice packs on but it may get swollen further. It's better not to aggravate the injury," Yuki said.

"Definitely it's disappointment you don't get many chances to play in Grand Slam. Hopefully, I will be fine soon," he added.

Sania, meanwhile, lost in straight sets to Kazakhstan's Galina Voskoboeva. She went down 4-6 6-7 (3) in a contest lasting a little over an hour and a half.

Sania, who has never gone beyond the second round at Roland Garros, had little match practice going into the clay court event.

The Indian's rustiness was quite evident in the six double faults she committed in the very first set.

Sania's failure to convert any of the four break points that she earned only added to her problems.

Voskoboeva converted a crucial break in the seventh game to clinch the first set in 46 minutes.

Sania put up a slightly better show in the second set and cut down on her double faults but 14 unforced errors pulled her back.

After losing her serve twice, Sania broke back to take the set into a tie-breaker.

But Voskoboeva, who had lost to Sania in their only past encounter, dominated the proceedings thereafter and clinched the tie-breaker 7-3.

Sania is still in fray in the doubles event where she has teamed up with Taipei's Chia-Jung Chuang.

Sania and Chuang, seeded 14th, will open their campaign against Turk-Belgian pair of Ipek Senoglu and Yanina Wickmayer.