Andy Roddick became another high-profile casualty of the second round after crashing to defeat against Janko Tipsarevic.

Following the demise of former champion Maria Sharapova in the women's draw earlier in the day, sixth seed Roddick saw his SW19 challenge ended by a 6-7 (5/7) 7-5 6-4 7-6 (7/4) loss on Centre Court.

The players had met just once before, also at Wimbledon, when Roddick battled back from a set down to see off the Serbian in four sets in a first-round match two years ago.

American ninth seed James Blake was dumped out with a 6-3 6-7 4-6 6-4 6-4 defeat by Rainer Schuettler of Germany.

Blake has never progressed beyond the third round at the All England Club while Schuettler, ranked 94 in the world, continues to negotiate unchartered waters at SW19.

Richard Gasquet's all-French showdown with Sebastien Grosjean ended prematurely with the eighth seed 6-2 6-2 ahead.

Grosjean was forced to retire in the third set with a thigh injury.

Czech 16th seed Radek Stepanek was taken to five sets by Viktor Troicki but rallied strongly to triumph 6-7 6-7 6-3 6-1 6-2.