LeBron James and Shaquille O'Neil led Cleveland Cavaliers to a 105-89 rout of Memphis Grizzlies as they remained dominant in the chase for the play-off places.

The Cavs lead the Central Division and are also the top-ranked team across the Eastern Conference, and James' 22 points backed by an O'Neal double-double saw them cement that position in dominant fashion.

South-East Division leaders Orlando Magic, Cleveland's nearest challengers in the East, saw off Milwaukee Bucks 99-82.

Dwight Howard led the way with 22 points, with a one-sided 27-10 second period holding the key to Orlando's success.

The remaining play-off challengers in action, Atlanta Hawks, Toronto Raptors and Chicago Bulls, all suffered surprise defeats.

Chris Bosh's 35 points went to waste as the Raptors were beaten 130-115 by Indiana Pacers, for whom Danny Granger poured in 23 points and Troy Murphy added 20.

Joe Johnson performed even better in vain with 37 points for the Hawks as Kevin Durant's 33 led Oklahoma City Thunder to a 106-99 triumph.

And Eric Gordon led all scorers with 24 as Los Angeles Clippers inflicted a 90-82 defeat on the Bulls, for whom Great Britain forward Luol Deng top-scored with 18.

Elsewhere, a 28-19 third quarter helped Detroit Pistons beat lowly New Jersey Nets 97-93 while Houston Rockets saw off Golden State 119-97 despite 34 points from the Warriors' Monta Ellis.